NUMERO: #20231221

Título: LESIONS IN THE ORAL MUCOSA ASSOCIATED WITH THE USE OF CHECKPOINT INHIBITORS: A BIBLIOMETRIC AND CRITICAL REVIEW

Nome do Apresentador: Jefferson da Rocha TENORIO

Categoria do Trabalho: Painel de Revisões narrativas ou sistemáticas (PRN)

Área Temática: Odontologia para pacientes especiais

Resumo: Aims: Immune-related adverse events linked to the use of immune checkpoint inhibitors (ICIs) have become increasingly frequent. To perform a bibliometric and critical review of the general panorama of publications on oral mucosal lesions (OML) associated with ICIs. Methods and Results: Systematized searches were performed in four databases. The included studies were organized and bibliometric and clinical data were extracted and analyzed using VantagePointT and Microsoft Excel®. Most of the 35 included studies were reports or case series (n=33/94,2%). The American authors stood out (n=17/48,5%), with the majority presenting only one publication. Independent groups carried out most of the publications (n=31/88,5%). Over the years, publications have increased for users of nivolumab and pembrolizumab. In 21 studies (60%), OML were more common in men, between the 6th and 9th decades of life and who had lung carcinoma (n=13/37,1%). Pembrolizumab (n=17/48,5%) was the most used ICI. The patients were affected by one or more OML, including: ulcers (n=28/80%) and erythema (n=11/31,4%). Systemic corticosteroids (n=24/68,5%) and the discontinuation of ICI use (n=18/51,4%) were the main approaches used. Conclusion: OML related to the use of ICIs have become increasingly common. More accurate data need to be published.

Autor 1:  Jefferson da Rocha TENORIO

E-mail 1:  [email protected]

Autor 2:   Juliana da Silva Rangel Pereira

E-mail 2:  [email protected]

Autor 3 :  Lucas Alves Jural

E-mail 3:  [email protected]

Autor 4:  Mariana Batista Ribeiro-Lages

E-mail 4:  [email protected]

Autor 5:  Lucianne Cople Maia

E-mail 5:  [email protected]

Autor 6:  Larissa Soares Lima da Silva

E-mail 6:  [email protected]

Autor 7:  Bruno Augusto Benevenuto de Andrade

E-mail 7:  [email protected]