NUMERO: #20231182

Título: SARCOMATOID CARCINOMA OF THE ORAL CAVITY: STUDY OF THREE CHALLENGING CASES

Nome do Apresentador: Luccas LAVAREZE

Categoria do Trabalho: Painel de caso clínico (PCC)

Área Temática: Patologia Oral

Resumo: Sarcomatoid Carcinoma (ScC) is a highly aggressive subtype of squamous cell carcinoma associated with a poor prognosis. Histologically, ScC has varying proportions of epithelial carcinomatous and mesenchymal sarcomatous components, making the diagnosis challenging. We present here three challenging cases of primary ScC. Patients were presented with ulcerated exophytic lesions in the lower lip (two) or hard palate (one) with no history of radiation therapy. Microscopic analysis revealed infiltrative malignant spindle cells interspersed with epithelioid giant and/or bizarre cells. Immunohistochemical showed variability in p63, vimentin, AE1/AE3, and CK14 expression. S100 was positive and αSMA was focally positive in one case. In conclusion, ScC is a lesion with a varied immunohistochemical profile and needs to be evaluated along with clinicopathological findings to be diagnosed correctly. Thus, ScC should be considered as a differential diagnosis when polypoid lesions with a morphological variation of malignant cells are presented in the lower lip.

Autor 1:  Luccas LAVAREZE

E-mail 1:  [email protected]

Autor 2:   Moisés Willian Aparecido GONÇALVES

E-mail 2:  [email protected]

Autor 3 :  Carlos Takahiro CHONE

E-mail 3:  [email protected]

Autor 4:  Alfio José TINCANI

E-mail 4:  [email protected]

Autor 5:  Erika Said Abu EGAL

E-mail 5:  [email protected]

Autor 6:  Albina ALTEMANI

E-mail 6:  [email protected]

Autor 7:  Fernanda Viviane MARIANO

E-mail 7:  [email protected]