NUMERO: #20231160

Título: GNATHIC ADENOID CYSTIC CARCINOMA: A SYSTEMATIC REVIEW OF THE CLINICOPATHOLOGICAL AND SURVIVAL PROFILE

Nome do Apresentador: Luccas LAVAREZE

Categoria do Trabalho: Painel de Revisões narrativas ou sistemáticas (PRN)

Área Temática: Estomatologia

Resumo: Objective: To evaluate the clinicopathological characteristics, survival rate, and prognostic factors of primary intraosseous adenoid cystic carcinoma (IACC) in the jaws. Study Design: We conducted a literature search on MEDLINE/PubMed, Scopus, and Embase. The inclusion criteria were articles with IACC diagnosed in the jaws. Exclusion criteria included studies with insufficient demographic information, follow-up, and inconclusive histopathological diagnosis. Results: A total of 55 cases of IACC were reported among 27 studies. The mean age of diagnosis was 56.4±19.6 years, and the male-to-female ratio was 1:1.2. IACC typically presents as a slow-growing (36,4%), symptomatic mass (87.3%), with a significant incidence in the mandible (69.1%). Radiographically, IACC manifested as an ill-defined destructive lesion (40%), while histologically, the tumor exhibited a cribriform pattern in most cases (32.7%). Local recurrence was seen in 12.7%, while local and distant metastases were seen in 3.6% and 12.7% of cases. Solid tumors and distant metastases were predictive of poor disease-free survival (p=0.040; p=0.043). The 2- and 5-year overall survival rates were 57.9% and 53.8%, respectively. Conclusion: IACC affects middle-aged adults, with no sex preference. The most common site of occurrence is the posterior mandible. Solid tumors and distant metastases are associated with a poorer prognosis.

Autor 1:  Luccas LAVAREZE

E-mail 1:  [email protected]

Autor 2:   João Figueira SCARINI

E-mail 2:  [email protected]

Autor 3 :  Reydson Alcides DE LIMA-SOUZA

E-mail 3:  [email protected]

Autor 4:  Rogério de Oliveira GONDAK

E-mail 4:  [email protected]

Autor 5:  Erika Said Abu EGAL

E-mail 5:  [email protected]

Autor 6:  Albina ALTEMANI

E-mail 6:  [email protected]

Autor 7:  Fernanda Viviane MARIANO

E-mail 7:  [email protected]