NUMERO: #20231156

Título: DNA PLOIDY AND CELL CYCLE CHARACTERIZATION OF BENIGN SALIVARY TUMORS PRESENTING MYOEPITHELIAL/ABLUMINAL DIFFERENTIATION

Nome do Apresentador: Gustavo de Souza VIEIRA

Categoria do Trabalho: Painel de pesquisa científica (PPC)

Área Temática: Patologia Oral

Resumo: Objective: We aimed to characterize the DNA ploidy and cell cycle phases presented by tumor cells from benign salivary gland neoplasms with myoepithelial/abluminal differentiation. Study design: Flow cytometric analysis of the DNA was performed using tissue-extracted cells from paraffin-embedded sections of seventeen pleomorphic adenomas, six basal cell adenomas, five myoepitheliomas, and nine normal salivary glands (control sample). The present study was approved by the research ethics committee (Ref. number: 5.853.891). Results: Females were predominant in all study groups, with an average age between the 5th and 6th decades of life. Most tumors were located in the parotid gland, often presenting as a nodule. Similarly, as in the normal salivary gland, the percentage of cells from the three tumor groups was vastly higher in the G1 phase of the cell cycle, with averages ranging from 79.58% to 81.61%. Through the variance tests, our results demonstrated that there was no statistical difference when comparing the percentages of the cell cycle phases between the groups (Phase G1: p=0.649; Phase S: p=0.503; Phase G2: p=0.517; 5cER: p=0.853). Conclusion: Our results depict a uniformity of DNA ploidy among benign neoplasms similar to that of normal salivary glands.

Autor 1:  Gustavo de Souza VIEIRA

E-mail 1:  [email protected]

Autor 2:   Tayná Figueiredo MACIEL

E-mail 2:  [email protected]

Autor 3 :  Moisés Willian Aparecido GONÇALVES

E-mail 3:  [email protected]

Autor 4:  Erika Said Abu EGAL

E-mail 4:  [email protected]

Autor 5:  Albina Messias ALTEMANI

E-mail 5:  [email protected]

Autor 6:  Marcelo SPERANDIO

E-mail 6:  [email protected]

Autor 7:  Fernanda Viviane MARIANO

E-mail 7:  [email protected]