NUMERO: #20231093

Título: LARGE CELL NEUROENDOCRINE CARCINOMA FOLLOWING HIGH-DOSE RADIOTHERAPY FOR SINONASAL UNDIFFERENTIATED CARCINOMA

Nome do Apresentador: Gustavo de Souza VIEIRA

Categoria do Trabalho: Painel de caso clínico (PCC)

Área Temática: Patologia Oral

Resumo: A 47-year-old male patient presented with a 5-month history of headaches and diplopia. No comorbidities were reported. MRI showed an expansive image affecting the ethmoid sinus and nasal cavity bilaterally (56x40x37mm), extending intracranially and into the orbits. Incisional biopsy analysis revealed a sinonasal undifferentiated carcinoma (T4aN0M0). Induction chemotherapy with TPF protocol added to CDDP cycles associated with high-dose radiotherapy were performed, with subsequent complete remission. After 45 months of follow-up, the patient presented a painful midfacial swelling. CT scan revealed a destructive image extending from the maxillary sinus to the intracranial region, with multiple regional lymphadenopathies. Microscopic examination showed a poorly differentiated tumor with large round cells. An immunohistochemistry panel revealed positivity for epithelial markers and a diffuse expression of neuroendocrine markers (CD56 and synaptophysin), a feature not previously observed in the initial lesion. Diagnosis of large cell neuroendocrine carcinoma was established, and surgical-oncologic treatment was performed with subsequent follow-up.

Autor 1:  Gustavo de Souza VIEIRA

E-mail 1:  [email protected]

Autor 2:   Carlos Takahiro CHONE

E-mail 2:  [email protected]

Autor 3 :  Taciane Adami de ARRUDA

E-mail 3:  [email protected]

Autor 4:  Ligia Traldi MACEDO

E-mail 4:  [email protected]

Autor 5:  Erika Said Abu EGAL

E-mail 5:  [email protected]

Autor 6:  Albina Messias ALTEMANI

E-mail 6:  [email protected]

Autor 7:  Fernanda Viviane MARIANO

E-mail 7:  [email protected]