NUMERO: #20230897

Título: EXUBERANT MERKEL CELL CARCINOMA OF THE FACE

Nome do Apresentador: Thamyres Campos FONSECA

Categoria do Trabalho: Painel de caso clínico (PCC)

Área Temática: Patologia Oral

Resumo: Merkel cell carcinoma (MCC) is a primary cutaneous neuroendocrine carcinoma of aggressive behavior that usually appears as a rapidly growing violaceous nodule or plaque in the sun-damaged skin of elderly Caucasians. It is microscopically characterized by small to intermediate round blue cells with a salt-and-pepper chromatin pattern positive for neuroendocrine and epithelial markers. We herein contribute with a rare case of exuberant MCC of the face. An otherwise healthy 82-year-old woman presented with a 6 x 5.5 cm fast-growing, painful ulcerated nodule in the right cheek of unknown duration. Microscopically, there were infiltrative small round cells with pleomorphic nuclei and granular chromatin, which were positive for pan-cytokeratin and CK20 (paranuclear dot-like pattern), chromogranin and synaptophysin (cytoplasmic pattern), and for CD56 (membrane pattern). The Ki-67 index labeling was 80%. The final diagnosis was MCC. Clinicians should consider MCC during evaluation of a large-sized violaceous nodule of the face.

Autor 1:  Thamyres Campos FONSECA

E-mail 1:  [email protected]

Autor 2:   Thayanne Oliveira de Freitas Gonçalves

E-mail 2:  [email protected]

Autor 3 :  Lindinalva Cavalcanti

E-mail 3:  [email protected]

Autor 4:  Paula Perrotta dos Reis Santos

E-mail 4:  [email protected]

Autor 5:  Michelle Agostini

E-mail 5:  [email protected]

Autor 6:  Aline Corrêa Abrahão

E-mail 6:  [email protected]

Autor 7:  Mario José Romañach

E-mail 7:  [email protected]