NUMERO: #20230656

Título: ORAL MANIFESTATIONS OF HISTOPLASMOSIS: A CASE REPORT

Nome do Apresentador: Talytha Barbosa da ROCHA

Categoria do Trabalho: Painel de caso clínico (PCC)

Área Temática: Patologia Oral

Resumo: Histoplasmosis is a systemic mycosis caused by Histoplasma capsulatum, a dimorphic
fungus. Its oral presentation is more common in the disseminated form of the disease. A 70-
year-old male patient, smoker, with history of oropharyngeal cancer, who was referred for
evaluation of painful ulceration affecting lip, for approximately 15 days. Intraoral
examination revealed ulcerated lesions located in lower lip and tongue. Clinic hypothesis was
syphilis, and incisional biopsy was performed. Histopathological analysis revealed non-
caseating granulomatous inflammation composed of epithelioid macrophages. Periodic Acid-
Schiff (PAS) staining demonstrated small oval yeasts. Serological tests were negative for
anticardiolipin and positive for Histoplasma capsulatum (M band). Based on this, diagnosis
of histoplasmosis was established. Radiographic exam no revealed pulmonary changes.
Patient underwent antifungal therapy (itraconazole - 200mg/45 days). Complete remission of
oral lesions at 30 days. Follow-up of 18 months without signs of recurrence of oral
manifestations.

Autor 1:  Talytha Barbosa da ROCHA

E-mail 1:  [email protected]

Autor 2:   Sarah dos Santos MARTINS

E-mail 2:  [email protected]

Autor 3 :  Everton Lindolfo da SILVA

E-mail 3:  [email protected]

Autor 4:  John Lennon Silva CUNHA

E-mail 4:  [email protected]

Autor 5:  Manuel Antonio GORDÓN-NÚÑEZ

E-mail 5:  [email protected]

Autor 6:  Pollianna Muniz ALVES

E-mail 6:  [email protected]

Autor 7:  Cassiano Francisco Weege NONAKA

E-mail 7:  [email protected]