NUMERO: #20230653

Título: ORAL MANIFESTATIONS OF GRAFT-VERSUS-HOST DISEASE: REPORT OF TWO CASES

Nome do Apresentador: Talytha Barbosa da ROCHA

Categoria do Trabalho: Painel de caso clínico (PCC)

Área Temática: Patologia Oral

Resumo: Graft-versus-host disease (GVHD) is an important complication of patients submitted to
allogeneic hematopoietic stem cell transplantation (AHCT), and oral cavity is involved in
>80% of the cases. We report two cases of oral GVHD. Case 1: A 58 years-old male patient,
black, with a 4-year history of AHCT for treatment of acute myeloid leucemia. Extraoral
examination exhibited depigmented areas in the skin. Intraoral examination showed striae-
associated whitish plaques, symptomatic, affecting buccal mucosa and tongue, for
approximately 10-months. It was prescribed clobetazol propionate gel for 07-days and
lasertherapy. Case 2: A 29 years-old female patient, white, with a 5-year history of AHCT for
treatment of acute myeloid leukemia, exhibited striae-associated whitish plaques and reddish
áreas, asymptomatic, affecting the tongue, for approximately 12-months. In both cases,
incisional biopsy was performed and histopathological analysis revealed liquenoid pattern
corresponding to oral GVHD. In both cases, follow-up of 24 months revealed control of oral
manifestations.

Autor 1:  Talytha Barbosa da ROCHA

E-mail 1:  [email protected]

Autor 2:   Raíssa Cássia Gomes ACIOLE

E-mail 2:  [email protected]

Autor 3 :  Daliana Queiroga Castro GOMES

E-mail 3:  [email protected]

Autor 4:  John Lennon Silva CUNHA

E-mail 4:  [email protected]

Autor 5:  Manuel Antonio GORDÓN-NÚÑEZ

E-mail 5:  [email protected]

Autor 6:  Cassiano Francisco Weege NONAKA

E-mail 6:  [email protected]

Autor 7:  Pollianna Muniz ALVES

E-mail 7:  [email protected]