NUMERO: #20230620

Título: POLYMORPHISMS IN NANOG ARE ASSOCIATED WITH ORAL LEUKOPLAKIA: CASE-CONTROL STUDY

Nome do Apresentador: Daniel GRIGOLO

Categoria do Trabalho: Painel de pesquisa científica (PPC)

Área Temática: Patologia Oral

Resumo: Objective: To investigate the association of NANOG polymorphisms with oral leukoplakia. Material and methods: In this case-control study, 68 cases of oral leukoplakia, and 21 of normal oral mucosa (control) were submitted to genotyping of tagSNPs polymorphisms: rs877716 and rs10845877 in NANOG, through real-time polymerase chain reaction (PCR). Pearson's chi-squared and Fisher's exact statistical tests were used, with a significance of 5%. Results: For the dominant genetic model of the G allele of rs877716, the genotypes AG+GG revealed higher frequency in subjects in the oral leukoplakia group than in control subjects (75.4 and 50% respectively; p=0.031). Subjects with this genotype were 3.063 times more likely to develop oral leukoplakia compared to subjects with AA. In the allelic genetic model, for rs10845877, the C allele was more frequent in subjects with leukoplakia than in control subjects (25 and 7.5% respectively; p=0.01). There was no association found in the other genetic models. Conclusion: Polymorphisms in NANOG are associated with oral leukoplakia.

Autor 1:  Daniel GRIGOLO

E-mail 1:  [email protected]

Autor 2:   Suelen Teixeira SCHEIFER

E-mail 2:  [email protected]

Autor 3 :  Arieli Carini MICHELS

E-mail 3:  [email protected]

Autor 4:  Filipe MODOLO

E-mail 4:  [email protected]

Autor 5:  Rafaela SCARIOT

E-mail 5:  [email protected]

Autor 6:  Maria Cassia Ferreira AGUIAR

E-mail 6:  [email protected]

Autor 7:  Aline Cristina Batista Rodrigues JOHANN

E-mail 7:  [email protected]