NUMERO: #20230583

Título: aPDT USED IN THE MANAGEMENT OF OSTEORADIONECROSIS. A PROMISING THERAPY

Nome do Apresentador: Fernanda das Neves LOPES

Categoria do Trabalho: Painel de caso clínico (PCC)

Área Temática: Estomatologia

Resumo: A 78-year-old male was diagnosed with Merkel's cell carcinoma of the base of the tongue. Treatment consisted of chemotherapy (carboplatin and etoposide) and 70Gy radiotherapy. Four years later, extraction of the tooth 38 was indicated due to periodontal diseases and osteoradionecrosis was established in this region. aPDT (Antimicrobial Photodynamic Therapy) using methylene blue 0.01% and red light (660 ± 10nm; 100mW) was performed weekly for 4 weeks. Afterwards, the patient was submitted to local bone debridement and the region healed completely. After 9 months, a new exposed bone was observed in the same region. Antibiotics were prescribed and weekly applications of aPDT were performed until the complete remission of bone exposure. The present study showed a case of osteoradionecrosis which had a satisfactory control using aPDT. Such technique was well tolerated. Moreover, controlled prospective study should be performed for better understanding its efficacy in the management of osteoradionecrosis.

Autor 1:  Fernanda das Neves LOPES

E-mail 1:  [email protected]

Autor 2:   Osias VIEIRA de Oliveira Filho

E-mail 2:  [email protected]

Autor 3 :  Graziella Chagas JAGUAR

E-mail 3:  [email protected]

Autor 4:  Saygo TOMO

E-mail 4:  [email protected]

Autor 5:  Rodrigo Nascimento LOPES

E-mail 5:  [email protected]

Autor 6:  Maria Stella Nunes Araujo MOREIRA

E-mail 6:  [email protected]

Autor 7:  Fabio de Abreu ALVES

E-mail 7:  [email protected]