NUMERO: #20230573

Título: MORPHOLOGICAL AND TISSUE-BASED MOLECULAR CHARACTERIZATION OF ORAL LESIONS IN PATIENTS WITH COVID-19: A LIVING SYSTEMATIC

Nome do Apresentador: Alini Cardoso SOARES

Categoria do Trabalho: Painel de pesquisa científica (PPC)

Área Temática: Estomatologia

Resumo: Objective: To integrate the morphological and tissue-based molecular characterization of oral lesions occurring in individuals infected by COVID-19 (OLICs).

Study design: This study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, Web of Science, Scopus, Ovid, Embase, and LILACS were searched to identify reports on OLICs with morphological and/or tissue-based molecular data.

Results: Four studies reporting five cases were included. Three patients were male, and the mean age of the individuals was 47.6 years. The most reported anatomical location was the palate (n=4), whereas ulcers were the most frequent clinical presentation (n=3). Histopathologically, all cases revealed cell vacuolization and exocytosis in the epithelial layer. In the mesenchymal layer, inflammatory cell infiltrate and thrombi/microvascular thrombosis were observed in three cases. Immunohistochemical reactions were performed in two cases. Both cases were negative for HHV-1, HHV-2, and CMV. One case revealed positivity for SARS-CoV-2 spike protein. No other molecular tests were found for the characterization of OLIC.

Conclusions: The pathological characteristics of OLICs are still unspecific. However, with the ongoing COVID-19 pandemic and well-documented new cases, whether OLICs are due to coinfections or has a primary origin can be determined.

Autor 1:  Alini Cardoso SOARES

E-mail 1:  [email protected]

Autor 2:   Felipe Martins SILVEIRA

E-mail 2:  [email protected]

Autor 3 :  Laura Borges KIRSCHNICK

E-mail 3:  [email protected]

Autor 4:  Manoela Domingues MARTINS

E-mail 4:  [email protected]

Autor 5:  Lauren Frenzel SCHUCH

E-mail 5:  [email protected]

Autor 6:  Alan Roger SANTOS-SILVA

E-mail 6:  [email protected]

Autor 7:  Ana Carolina Uchoa VASCONCELOS

E-mail 7:  [email protected]