NUMERO: #20230549

Título: OZONE THERAPY AND PHOTODYNAMIC THERAPY IN THE TREATMENT OF MANDIBULAR NECROSIS ASSOCIATED WITH DENOSUMAB

Nome do Apresentador: Beatriz Maia Medrado de ARAUJO

Categoria do Trabalho: Painel de caso clínico (PCC)

Área Temática: Estomatologia

Resumo: A 59-year-old patient with breast adenocarcinoma metastasis sought a Stomatology Service exhibiting mandibular bone exposure and presence of suppurative exudate in the region of a prosthesis on implants between units 41 and 44. The patient reported the use of Denosumab for two years after the diagnosis of bone and lung metastasis. The initial treatment included analgesia and continuous antibiotic therapy, with remained controlled infection. Ozone gas was applied to the soft tissues around the lesion, and it was also washed with ozonized water, once a week. In parallel, photodynamic therapy was performed with the application of methylene blue and laser photobiomodulation twice a week, for 6 months. After this period, it was observed mobility of the bone segment that supported the dental implants, and the fragment was surgically removed. The histopathological examination revealed bone necrosis. The patient is under follow-up and till this moment, no other local alterations are seen.

Autor 1:  Beatriz Maia Medrado de ARAUJO

E-mail 1:  [email protected]

Autor 2:   Maria Paula VIDAL Grisi

E-mail 2:  [email protected]

Autor 3 :  Gabriela BOTELHO Martins

E-mail 3:  [email protected]

Autor 4:  Alena Ribeiro Peixoto MEDRADO

E-mail 4:  [email protected]

Autor 5:  Roberta dos Santos TUNES

E-mail 5:  [email protected]

Autor 6:  Antônio Márcio Teixeira MARCHIONNI

E-mail 6:  [email protected]

Autor 7:  Silvia Regina de Almeida REIS

E-mail 7:  [email protected]