NUMERO: #20230498

Título: A SYSTEMATIC REVIEW OF THE CONTROVERSIAL GRANULAR CELL ODONTOGENIC FIBROMA

Nome do Apresentador: Raisa Jordana Geraldine SEVERINO LAZO

Categoria do Trabalho: Painel de Revisões narrativas ou sistemáticas (PRN)

Área Temática: Patologia Oral

Resumo: Background: Granular cell odontogenic fibroma (GCOF) is a controversial odontogenic neoplasm that has been reported over time under different names, and for a long time as a variant of ameloblastic fibroma. However, most authors agree that, due to the still uncertain origin of GCOF granular cells and their uncertain biological behavior, it would be better to keep it as a separate entity that still needs to be better understood.
Objective: In this context, the purpose of this study is to systematically review all available epidemiological, clinicopathological, imaging, immunohistological, therapeutic, follow-up and recurrence data of GCOF and to present a new case of this rare lesion.
Study Design: This review was conducted following PRISMA guidelines. An electronic search was performed in different databases until November 2022.
Results: Thirty-nine studies reporting fifty-three cases were included. The GCOF is a rare lesion and accounts for less than 5% of reported odontogenic tumors, with a higher prevalence in middle-aged and white women. This lesion occurs mainly in the posterior region of the mandible. Furthermore, according to the clinical, radiographic, and histopathologic characteristics, conservative treatment was the most used option, with recurrence in only two cases.
Conclusions: GCOF remains controversial due to unresolved histogenesis.
FACEPE and CAPES founding.

Autor 1:  Raisa Jordana Geraldine SEVERINO LAZO

E-mail 1:  [email protected]

Autor 2:   Allan Vinícius MARTINS-DE-BARROS

E-mail 2:  [email protected]

Autor 3 :  Jéssica DA SILVA CUNHA

E-mail 3:  [email protected]

Autor 4:  Rómulo Augusto DE PAIVA MACEDO

E-mail 4:  [email protected]

Autor 5:  Mohammed N. ISLAM

E-mail 5:  [email protected]

Autor 6:  Belmiro Cavalcanti DO EGITO VASCONCELOS

E-mail 6:  [email protected]

Autor 7:  Marianne de Vasconcelos CARVALHO

E-mail 7:  [email protected]