NUMERO: #20230496

Título: CLINICOPATHOLOGICAL STUDY AND SURVIVAL OUTCOMES OF SIALOBLASTOMA: A SYSTEMATIC REVIEW

Nome do Apresentador: Vitória Maria Sousa CRUZ

Categoria do Trabalho: Painel de Revisões narrativas ou sistemáticas (PRN)

Área Temática: Patologia Oral

Resumo: Objective: To analyze the clinical and histopathological features, treatment, and outcome of sialoblastoma. Study design: Case reports and case series of sialoblastoma with histopathological confirmation were searched in PubMed, Embase, Scopus, Web of science and in the gray literature. Results: A total of 52 studies (62 patients) were identified. There was no gender predilection, the patients were mainly affected at birth (N=38; 61.3%), and the parotid was the most common site (N=28; 45.2%). In the log-rank test, there was a significant increase in disease-associated survival in patients younger than 1 year of age (82.8%; [CI: 317-493.7]; p=0.003), individuals with tumors in major salivary glands (79.4%; [CI: 280.1-467.3]; p= .005), patients without metastases (77.8%; [CI: 95.9 - 151.2]; p= .011), encapsulated lesions (85.7%; [CI: 285.3 - 541.6]; p=0.0001), congenital tumors (83.3%; [CI: 283.0 - 488.8]; p= 0.0001) and lesions without perineural invasion (89.5%; [CI: 117.2 - 161.1]; p= 0.035). Kaplan-Meier curves estimated overall survival and disease-free survival at 5 years of 95.5% and 68.1%, respectively. In the multivariate Cox regression model, only the presence of metastasis was identified as an independent prognostic factor (hazard ratio [HR]=9.81; p=0.010). Conclusion: Although sialoblastoma presents good prognosis, the tumor has a high recurrence rate.

Autor 1:  Vitória Maria Sousa CRUZ

E-mail 1:  [email protected]

Autor 2:   Maria Eduarda PÉREZ-DE-OLIVEIRA

E-mail 2:  [email protected]

Autor 3 :  Éder Gerardo dos Santos LEITE

E-mail 3:  [email protected]

Autor 4:  Brendo Vinicius Rodrigues LOUREDO

E-mail 4:  [email protected]

Autor 5:  Hélen Kaline Farias BEZERRA

E-mail 5:  [email protected]

Autor 6:  Pablo Agustin VARGAS

E-mail 6:  [email protected]

Autor 7:  Danyel Elias da Cruz PEREZ

E-mail 7:  [email protected]