NUMERO: #20230491

Título: GENETIC AND IMMUNOHISTOCHEMICAL ASSOCIATION ANALYSIS OF SOX-2 IN ORAL LEUKOPLAKIA

Nome do Apresentador: Thais Caroline Dos SANTOS

Categoria do Trabalho: Painel de pesquisa científica (PPC)

Área Temática: Patologia Oral

Resumo: Objective: To investigate the association of SOX2 polymorphism with oral leukoplakia and to compare with immunohistochemistry expression of SOX-2.
Study design: Case control study. The sample was composed by 64 patients with oral leukoplakia and 20 presenting normal oral mucosa (control group) that were submitted to genotyping of SOX2 gene polymorphisms rs77677339 (G/A) by PCRP in real time and to immunohistochemistry for SOX-2 (basal epithelium expression, suprabasal and total; nuclear area and intensity). The statistical tests included Chi-square and Fisher´s Exact Test, 5% of significance.
Results: There was no significance (p=0,578) in genotypes distribution for rs77677339 (G/A) marker between oral leukoplakia and control. The genotype GG (96,9%) was observed in oral leukoplakia and 100% in controls. The genotype GA was not observed in the controls. The statistical crossings between immunohistochemistry and genetics results were not significant.
Conclusion: There was no association of rs77677339 (G/A) polymorphism and immunohistochemistry on oral leukoplakia, but in the presence of allele A on heterozygotes with oral leukoplakia suggests an important role of this allele as a risk marker.

Autor 1:  Thais Caroline Dos SANTOS

E-mail 1:  [email protected]

Autor 2:   Suelen Teixeira SCHEIFER

E-mail 2:  [email protected]

Autor 3 :  Arieli Carini MICHELS

E-mail 3:  [email protected]

Autor 4:  Filipe MODOLO

E-mail 4:  [email protected]

Autor 5:  Cleber Machado de SOUZA

E-mail 5:  [email protected]

Autor 6:  Maria Cassia Ferreira AGUIAR

E-mail 6:  [email protected]

Autor 7:  Aline Cristina Batista Rodrigues JOHANN

E-mail 7:  [email protected]