NUMERO: #20230446

Título: ORAL PIGMENTATION CAUSED BY CHRONIC USE OF CHLOROQUINE: REPORT OF TWO CASES

Nome do Apresentador: Gloria Beatriz do Nascimento ANDRADE

Categoria do Trabalho: Painel de caso clínico (PCC)

Área Temática: Patologia Oral

Resumo: Here, we aimed to report two cases of oral pigmentation related to chronic use of chloroquine. The first, a female 48 years old, was complaining about "dry mouth and eyes, and itchy skin". She was diabetic, has systemic lupus erythematosus (SLE), and was using glibenclamide, gabapentin, and hydroxychloroquine. On physical examination, brownish spots were noted on the back and arm, and a grayish-purple spot on the alveolar ridge and hard palate. The second, a 56-year-old female was complaining of "dry mouth and sores", has arthritis, SLE, and was using gabapentin, and hydroxychloroquine. Intraoral examination revealed ​​a brownish-purple spots on the hard palate and cheek. Both were negative for Addison´s Disease (cortisol and ACTH). Incisional biopsy was requested for the first patient which revealed melanocytes phagocytosed by macrophages. Based on this, the diagnosis of pigmentation from chronic use of chloroquine was reached. Both were advised and are still being monitored.

Autor 1:  Gloria Beatriz do Nascimento ANDRADE

E-mail 1:  [email protected]

Autor 2:   Hélder Domiciano Dantas MARTINS

E-mail 2:  [email protected]

Autor 3 :  Livian Isabel de Medeiros CARVALHO

E-mail 3:  [email protected]

Autor 4:  Eduarda Gomes Onofre de ARAÚJO

E-mail 4:  [email protected]

Autor 5:  Paulo Rogério Ferreti BONAN

E-mail 5:  [email protected]