NUMERO: #20230445

Título: IMMUNOHISTOCHEMICAL EXPRESSION OF ANGIOTENSIN-CONVERTING ENZYMES 1 AND 2 IN ORAL SQUAMOUS CELL CARCINOMA

Nome do Apresentador: Kamilla PASSOS

Categoria do Trabalho: Painel de pesquisa científica (PPC)

Área Temática: Patologia Oral

Resumo: Objective: To evaluate the immunohistochemistry expression of angiotensin-converting enzyme (ACE) 1 and 2 in oral squamous cell carcinomas (SCC). Study Design: Retrospective cross-sectional study based on clinicopathological and immunohistochemical analyses of 30 samples of oral SCC and 10 samples of healthy oral mucosa. The immunohistochemical evaluation was performed using a semi-quantitative scoring system, which analyzes the percentage of positive cells and their staining intensity to obtain the staining index (CI). Statistical analysis was performed to evaluate the associations between the clinicopathological and immunohistochemical variables (p < 0.05). Results: ACE 1 and 2 were expressed, in different percentages and intensities, in the cytoplasm of tumor and stromal cells, particularly fibroblasts present in the tumor microenvironment. ACE1 expression were higher in tumor cells (p<0.05) and ACE2 in healthy tissues (p<0.05). There was association between ACE1 expression and poorly differentiated tumors (p=0.001), and immunostaining of ACE1 and 2 in tumor cells was positively associated with immunostaining of these proteins in underlying stromal tissues (p <0.05). Conclusion: ACE1 expression was higher in poorly differentiated tumors. Further studies are needed to evaluate this marker as a potential prognostic marker, besides the possibility of using the renin-angiotensin system enzymes as probable therapeutic targets in oral SCC.

Autor 1:  Kamilla PASSOS

E-mail 1:  [email protected]

Autor 2:   Augusto LEONEL

E-mail 2:  [email protected]

Autor 3 :  Fernanda OLIVEIRA

E-mail 3:  [email protected]

Autor 4:  Jurema DE CASTRO

E-mail 4:  [email protected]

Autor 5:  Elaine Carvalho

E-mail 5:  [email protected]

Autor 6:  Moacyr RÊGO

E-mail 6:  [email protected]

Autor 7:  Daniel PEREZ

E-mail 7:  [email protected]