NUMERO: #20230441

Título: ORAL VERRUCIFORM XANTHOMA IN A PATIENT WITH HISTORY OF HEMATOPOIETIC CELL TRANSPLANTATION: CASE REPORT

Nome do Apresentador: Farah Essgui Orellana MARTINEZ

Categoria do Trabalho: Painel de caso clínico (PCC)

Área Temática: Patologia Oral

Resumo: Oral verruciform xanthoma (OVX) is an uncommon benign lesion of unknown etiology that resemble other papillary lesions. A 26-year-old male with a history of hematopoietic cell transplantation for treatment of acute myeloid leukemia, reported the appearance of an asymptomatic lesion with 5 months of evolution. Clinically, a sessile verrucous lesion with a slightly yellowish appearance and 1 cm in diameter was observed, located in the alveolar ridge. The differential diagnosis included squamous papilloma and verrucous carcinoma, for which an incisional biopsy was performed. Microscopically, it exhibited papillary epithelial hyperplasia forming uniformly elongated bulbous ridges, under which numerous xanthomized cells confined to the conjunctival papillae can be observed. The CD68+ immunohistochemical reaction showed xanthomized macrophages, allowing the histopathological diagnosis of OVX. Subsequently, an excisional biopsy was performed, and the patient is currently free of the lesion. The histopathology and clinical history are highlighted as auxiliary methods in the diagnosis of OVX.

Autor 1:  Farah Essgui Orellana MARTINEZ

E-mail 1:  [email protected]

Autor 2:   Thâmara Manoela Marinho BEZERRA

E-mail 2:  [email protected]

Autor 3 :  Ana Paula Negreiros Nunes ALVES

E-mail 3:  [email protected]

Autor 4:  Fabricio Bitu SOUSA

E-mail 4:  [email protected]

Autor 5:  Karuza Maria Alves PEREIRA

E-mail 5:  [email protected]

Autor 6:  Mário Rogério Lima MOTA

E-mail 6:  [email protected]