NUMERO: #20230148

Título: APPLICABILITY OF ANTIMICROBIAL PEPTIDES IN VIRAL LESIONS OF THE ORAL CAVITY

Nome do Apresentador: Belmiro Ferreira Neves NETO

Categoria do Trabalho: Painel de Revisões narrativas ou sistemáticas (PRN)

Área Temática: Patologia Oral

Resumo: OBJECTIVE: To explore studies on useness and effectiveness of antimicrobial peptides in viral oral lesions. STUDY DESIGN: A bibliographic review was conducted in Pubmed, Web of Science and Scielo databases, using as descriptors "antimicrobial peptides", "virus", "treatment" and "oral". RESULTS: From a total of 64 publications, 3 studies published between 2000 and 2023 were selected. The use of peptides represents an important therapy, which acts in a targeted way to kill viral agents. Therefore, these active molecules can prevent the virus from binding to host cell receptors, inhibiting the viral cycle. It has proven been demonstrated that the use of defensins against enveloped viruses that leads to oral infections act on glycoproteins, which are necessary for the membrane fusion process. Furthermore, it was seen that the HIV-1 virus promotes the expression of β-defensins in cells of oral epithelium, molecules which act blocking viral replication through a direct interaction with virions and modulating the CXCR4 co-receptor. CONCLUSION: The application of antimicrobial peptides is a promissing alternative for therapies against viruses, due to the difficulty in developing resistance of viral agents, and thus contribute to better results in oral infections.

Autor 1:  Belmiro Ferreira Neves NETO

E-mail 1:  [email protected]

Autor 2:   Marina Isabela de Paula SOUSA

E-mail 2:  [email protected]

Autor 3 :  Débora Oliveira SANTOS

E-mail 3:  [email protected]

Autor 4:  Wigney Júnior Gonzaga CARVALHO

E-mail 4:  [email protected]

Autor 5:  Natália Ichii Paim COSTA

E-mail 5:  [email protected]

Autor 6:  Esteban Nicolas LORENZON

E-mail 6:  [email protected]

Autor 7:  Carla Silva Siqueira MIRANDA

E-mail 7:  [email protected]