NUMERO: #20230067

Título: ANALYSIS OF YES-ASSOCIATED PROTEIN IMMUNOEXPRESSION AND ITS INFLUENCE ON THE PROGRESSION OF BENIGN ODONTOGENIC LESIONS

Nome do Apresentador: Rani Iani Costa GONÇALO

Categoria do Trabalho: Painel de pesquisa científica (PPC)

Área Temática: Patologia Oral

Resumo: Objective: To analyze the immunohistochemical expression of YAP protein and correlate it with markers involved in cell proliferation and apoptosis in benign epithelial odontogenic lesions. Study design: The sample consisted of 95 cases of odontogenic lesions - 25 dentigerous cysts (DCs), 30 odontogenic keratocyst (OKCs), 30 conventional AMB (C-AMBs), and 10 unicystic AMB (U-AMBs). Ten dental follicles (DF) specimens were selected as control group. The immunohistochemical technique was performed on the tissue sections by using YAP, cyclin D1, Ki-67, and Bcl-2 antibodies, and their immunoexpression analysis was performed qualitatively and quantitatively. Collected data were submitted for descriptive and statistical analysis (p ≤ 0.05). Results: YAP immunoexpression was significantly higher in OKCs, especially in the basal and parabasal layers, followed by U-AMBs and C-AMBs, which showed moderate immunoreactivity, predominantly in peripheral cells. In addition, there were significant differences in YAP immunoexpression between the analyzed groups, with statistically significant correlations between YAP and cyclin D1 in DCs and U-AMBs, and between YAP and Ki-67 in U-AMBs (p < 0.05). However, between YAP and Bcl-2 immunoexpression, there were no statistically significant correlation among the groups. Conclusion: YAP may influence the cell proliferation of odontogenic cysts and tumors epithelium, thus helping with their progression.

Autor 1:  Rani Iani Costa GONÇALO

E-mail 1:  [email protected]

Autor 2:   Julliany Taverny SOUSA

E-mail 2:  [email protected]

Autor 3 :  Carla Samily de Oliveira COSTA

E-mail 3:  [email protected]

Autor 4:  Rodrigo Porpino MAFRA

E-mail 4:  [email protected]

Autor 5:  Leorik Pereira da SILVA

E-mail 5:  [email protected]

Autor 6:  Denise Hélen Imaculada Pereira de OLIVEIRA

E-mail 6:  [email protected]

Autor 7:  Lélia Maria Guedes QUEIROZ

E-mail 7:  [email protected]