Título: USE OF ANTITUMOR PEPTIDES AND HERBAL COMPOUNDS AS ANTINEOPLASTIC AGENTS
Nome do Apresentador: Wigney Júnior Carvalho GONZAGA
Categoria do Trabalho: Painel de Revisőes narrativas ou sistemáticas (PRN)
Área Temática: Oncologia
Resumo: Objective: The present work aims to detail the combination of antitumor peptides and herbal compounds, as antineoplastic agents. Study Design: A literature review was carried out in online databases with free access, "Pubmed" and "BVS", between the years 2021 and 2023. From a total of 48 articles 5 of them were selected according to the descriptors: "peptides", "phytotherapy and antineoplastic agents", written in English, Portuguese and Spanish. Results: The combined therapy of antitumor peptides and antineoplastic agents proved to be effective in all studies. Distinct cellular conformational changes were observed, induction of apoptosis by several ways, and induction of subcytotoxins capable of reducing the release of cytokines and chemokines released by cancer cells. However, the specificity of the antineoplastic action, as well as the possible side effects induced by this therapy, were not listed. Conclusion: the combined use of these compounds proved to be a promising therapeutic approach for the treatment of different types of cancer, since they can induce apoptosis through different ways. However, there is a need for further studies of antitumor peptides, as well as new herbal compounds and their combinations, listing their specificities and possible cellular damage the cells normal.
Autor 1: Wigney Júnior Carvalho GONZAGA
E-mail 1: [email protected]
Autor 2: Belmiro Ferreira Neves NETO
E-mail 2: [email protected]
Autor 3 : Emilene Ferreira de CASTRO
E-mail 3: [email protected]
Autor 4: Debora de Oliveira SANTOS
E-mail 4: [email protected]
Autor 5: Jáliston Júlio Lopes ALVES
E-mail 5: [email protected]
Autor 6: Esteban Nicolas LORENZON
E-mail 6: [email protected]
Autor 7: Carla Silva Siqueira MIRANDA
E-mail 7: [email protected]
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