NUMERO: #20230033

Título: MODULATION OF GENE EXPRESSION IN SKIN WOUND HEALING BY PHOTOBIOMODULATION THERAPY: A SYSTEMATIC REVIEW IN VIVO STUDIES

Nome do Apresentador: Alexia Antunes DELUCA

Categoria do Trabalho: Painel de Revisões narrativas ou sistemáticas (PRN)

Área Temática: Estomatologia

Resumo: Objective: To conducted a systematic review on publications which investigated gene expression after photobiomodulation therapy (PBM) during in vivo skin repair. Study design: Follow in Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) an electronic search was undertaken in six databases. The search strategy was conducted from the terms: low-level light therapy, gene expression and wound healing and their synonyms. The databases were consulted in October 2022 and no publication year limit was used. Results: Eleven studies were included in this review and the expression of 186 genes were evaluated. PBM modified the expression of several targets' genes studied, such as down-regulation of genes related to extracellular matrix proteases (MMP2 and MMP9) and pro-inflammatory cytokines (IL10 and IL6) and up-regulation of DNMT3A and BFGF. Conclusion: This review demonstrates that PBM is capable of regulating gene expression during wound healing. Most evidence showed a positive impact of PBM in regulating genes linked to inflammatory cytokines improving skin wound healing. Yet, the effects of PBM in genes involved in other mechanisms still need to be better understood.

Autor 1:  Alexia Antunes DELUCA

E-mail 1:  [email protected]

Autor 2:   Emily Ferreira Salles PILAR

E-mail 2:  [email protected]

Autor 3 :  Fernanda Thomé BROCHADO

E-mail 3:  [email protected]

Autor 4:  Tuany Rafaeli SCHMIDT

E-mail 4:  [email protected]

Autor 5:  Belkiss Câmara MÁRMORA

E-mail 5:  [email protected]

Autor 6:  Vivian Petersen WAGNER

E-mail 6:  [email protected]

Autor 7:  Manoela Domingues MARTINS

E-mail 7:  [email protected]