NUMERO: #20230030

Título: Efficacy of ozone therapy for oral mucosa wound healing: a systematic review and meta-analysis

Nome do Apresentador: Bruna do Amaral Ferreira Souza

Categoria do Trabalho: Painel de Revisões narrativas ou sistemáticas (PRN)

Área Temática: Estomatologia

Resumo: Objective: To conduct a systematic review and meta-analysis of the effectiveness of Ozone Therapy in healing mouth ulcers when compared to placebo or other active treatments.
Study design: The search was carried out using PubMed, EMBASE, Scopus, and Lilacs databases. Clinical trials, prospective and retrospective studies involving human participants were included. The Risk Ratio (RR) and the standardized mean difference (SMD) with 95% CI (confidence interval) were calculated. The ROBINS-I (Risk Of Bias In Non-randomized Studies of Interventions) assessment tool was used to detect bias.
Results: After the selection process, 12 studies were included. The meta-analysis showed that ozone therapy helps to reduce the size of the traumatic and autoimmune ulcers (RR=-0.44; 95% CI -0.71,-0.17; I²=0%). Regarding pain reduction, ozone was superior to placebo (RR=1.29, 95% CI -1.6 to -0.95); I²=0%), and equivalent to topical corticosteroid and low-level laser therapy (LLLT) (RR=0.26, 95% CI -0.27,0.78, p=0.34).
Conclusion: Ozone therapy is a good alternative for accelerating healing and reducing pain compared to placebo, and it is as effective as LLLT and topical corticosteroid therapy for both traumatic and autoimmune ulcers.

Autor 1:  Bruna do Amaral Ferreira Souza

E-mail 1:  [email protected]

Autor 2:   Deisi Romitti Maglia

E-mail 2:  [email protected]

Autor 3 :  Fernanda Visioli

E-mail 3:  [email protected]