NUMERO: #20230029

Título: ANTIMICROBIAL-ANTITUMORAL PEPTIDES. POTENCIAL MOLECULES TO TREAT ORAL CANCER AND BACTERIAL INFECTIONS: SYSTEMATIC REVIEW

Nome do Apresentador: Eduarda Fernandes LEAL

Categoria do Trabalho: Painel de Revisões narrativas ou sistemáticas (PRN)

Área Temática: Áreas afins no caráter multidisciplinar

Resumo: When analyzing the general situation regarding neoplasms, it is observed that microbial infections play a crucial role in its prognosis, especially in the oral cavity, where the connection between them becomes more evident. Unfortunately, the current pharmacological arsenal to treat these conditions has a low therapeutic spectrum, several unwanted side effects and high levels of resistance. OBJECTIVE: This work aimed to find dual-function peptides with potential antitumor and antimicrobial activity. STUDY DESIGN: For the selection of articles, a systematic search was carried out in PUBMED and Scielo databases, using "oral infections", "oral cancer" and "peptides" as descriptors. From a total of 77 papers, 10 were evaluated. RESULTS: There is no doubt that, with the increase in resistance against chemotherapy, antimicrobial peptides are appears as potential new therapeutic agents, as they exhibit direct cytotoxic activity against cancer cells. In addition, some peptides such as CA-MA 2 (cecropin-magainin 2) and Chrysophsin-1 are able to eliminate also pathogenic microorganisms related to oral diseases. CONCLUSION: Membranolytic peptides allow the intersection between antibiotic and antitumor activity, configuring promising therapeutic agents for the prevention/treatment of oral cancer and infections.

Autor 1:  Eduarda Fernandes LEAL

E-mail 1:  [email protected]

Autor 2:   Marco TORIBIO

E-mail 2:  [email protected]

Autor 3 :  Gabriela Jacob MONTEIRO

E-mail 3:  [email protected]

Autor 4:  Wigney Junior Carvalho GONZAGA

E-mail 4:  [email protected]

Autor 5:  Carla Silva Siqueira MIRANDA

E-mail 5:  [email protected]

Autor 6:  Esteban Nicolás LORENZÓN

E-mail 6:  [email protected]