NUMERO: #20230027

Título: IMMUNOTHERAPY WITH NATURAL COMPOUNDS IN HEAD AND NECK CANCER: A LITERATURE REVIEW

Nome do Apresentador: Ludmilla Dos Reis Silva

Categoria do Trabalho: Painel de Revisões narrativas ou sistemáticas (PRN)

Área Temática: Oncologia

Resumo: Objective: Considering the importance of immune system in the tumor progression and the need of new treatment options, this review highlights the major compounds evaluated as immunotherapeutic approach in HNSCC. Study design: A narrative review was performed with a search in PubMed and Scielo with the keywords "natural compound", "immunotherapy" and "head and neck cancer". Relevant articles that describe effects of natural compounds in immune system of head and neck cancer patients were included. Results: Several compounds, such as bitter melon, black raspberry, carnosic acid, Cordyceps militaris, curcumin, gamboic acid, Gan-Lu-Ying, green tea, honokiol, Operculina turpethum, Piper cubeba, resveratrol and Zheng-Sheng-Ping presented immunomodulatory properties in HNSCC, including changes in T cell infiltration, T cell function and cytokine release. The positive effects of the tested compounds lead to an increase of antitumor immune response. However, the majority of the compounds was evaluated only in vitro and in animal models. Conclusion: This review reinforces the potential use of herbal medicines in the context of antitumor therapy, which might be combined with conventional therapies. However, it is important to develop randomized clinical trials to assess whether the antitumor properties extend to the complex tumor microenvironment found in patients with head and neck carcinoma.

Autor 1:  Ludmilla Dos Reis Silva

E-mail 1:  [email protected]

Autor 2:   Anna Torrezani

E-mail 2:  [email protected]

Autor 3 :  Wigney Junior Carvalho Gonzaga

E-mail 3:  [email protected]

Autor 4:  Belmiro Ferreira Neves Neto

E-mail 4:  [email protected]

Autor 5:  Winícius Arildo Ferreira Araújo

E-mail 5:  [email protected]

Autor 6:  Vinícius Gonçalves de Souza

E-mail 6:  [email protected]

Autor 7:  Carla Silva Siqueira Miranda

E-mail 7:  [email protected]