NUMERO: #20230025

Título: EVALUATION OF CD4, CD8 AND PROGRAMMED DEATH LIGAND-1 EXPRESSION IN GIANT CELL LESIONS OF THE JAW

Nome do Apresentador: Mariana Rodrigues FERREIRA

Categoria do Trabalho: Painel de pesquisa científica (PPC)

Área Temática: Patologia Oral

Resumo: Objective: This study aims to characterize the expression of Programmed death ligand-1 (PD-L1) and correlate it with histopathological findings of central giant cell lesion (CGCL) and peripheral giant cell lesion (PGCL) of the jaw. Study design: In total, 16 samples of CGCL and 16 PGCL were submitted to hematoxylin and eosin stain and immunohistochemistry for PD-L1, CD4 and CD8. Statistical analysis was performed using SPSS software version 26.0 with Mann-Whitney and Spearman Correlation tests. Significant analysis was considered when p < 0.05. Results: No differences were found in clinical and histopathological parameters. CGCL presented more cases with CD4 expression when compared to PGCL, but no difference was found in CD8 and PD-L1 expression. Considering all the samples a positive correlation was found between PD-L1 expression and inflammatory infiltrate and CD8 expression. Conclusion: Considering the both groups, PD-L1 expression had a positive correlation with CD8 expression and inflammatory infiltrate, that could indicate an immunoregulatory profile of these cells and the potential of use of immunotherapy in these lesions. More studies should be developed in order to characterize the use of immune markers and immunotherapy in the both types of giant cell lesion in order to highlight pathogenic and therapeutic aspects.

Autor 1:  Mariana Rodrigues FERREIRA

E-mail 1:  [email protected]

Autor 2:   Vinícius Gonçalves de SOUZA

E-mail 2:  [email protected]

Autor 3 :  Rosy Iara Maciel de Azambuja RIBEIRO

E-mail 3:  [email protected]

Autor 4:  Adriano Mota LOYOLA

E-mail 4:  [email protected]

Autor 5:  Sérgio Vitorino CARDOSO

E-mail 5:  [email protected]

Autor 6:  Ludimila Paula Vaz CARDOSO

E-mail 6:  [email protected]

Autor 7:  Carla Silva Siqueira MIRANDA

E-mail 7:  [email protected]