NUMERO: #20230024

Título: STEREOLOGICAL ANALYSIS OF ACTINIC CHEILITIS AND LIP SQUAMOUS CELL CARCINOMA

Nome do Apresentador: Mariana Rodrigues FERREIRA

Categoria do Trabalho: Painel de pesquisa científica (PPC)

Área Temática: Patologia Oral

Resumo: Objective: This study aims to evaluate the potential of stereological analysis in prediction of tumor progression and aggressivity of potential malignant (actinic cheilitis - AC) and malignant (lip squamous cell carcinoma - LSCC) lip disorders. Study design: 27 samples of LSCC and 37 of AC were submitted to hematoxylin and eosin stain and histological analysis of gradation or dysplasia and stereological analysis of changed cells (tumor or dysplastic), inflammation, blood vessels, dyskeratosis, keratin pearls, necrosis and solar elastosis. Statistical analysis was performed using SPSS software version 26.0 with Spearman correlation and Mann-Whitney test, and a p value < 0.05 was adopted as significance. Results: LSCC samples presented significant percentages of morphological changed (tumor cells or dysplastic cells) and inflammatory cells when compared to AC. Stereological parameters were not correlated with dysplasia or tumor gradation. Conclusion: It is was noted that LSCC presented higher levels of changed cells and inflammatory cells when compared to AC, reflecting the higher proliferative and immunogenic properties of malignant disorders when compared to potentially malignant one. However, the stereological parameters were not correlated with markers of aggressivity in our sample, justifying the need for further evaluations to identify potential new biomarkers of aggressiveness in pathological analysis.

Autor 1:  Mariana Rodrigues FERREIRA

E-mail 1:  [email protected]

Autor 2:   José França Rezende NETO

E-mail 2:  [email protected]

Autor 3 :  Marco TORIBIO

E-mail 3:  [email protected]

Autor 4:  Felipe Fernandes de BRITO

E-mail 4:  [email protected]

Autor 5:  Gabriela Jacób MONTEIRO

E-mail 5:  [email protected]

Autor 6:  Vinícius Gonçalves de SOUZA

E-mail 6:  [email protected]

Autor 7:  Carla Silva Siqueira MIRANDA

E-mail 7:  [email protected]