NUMERO: #20230022

Título: THE COMBINATION OF PEPTIDES AND CISPLATIN FOR THE TREATMENT OF ORAL CANCER

Nome do Apresentador: Marco TORIBIO

Categoria do Trabalho: Painel de Revisões narrativas ou sistemáticas (PRN)

Área Temática: Oncologia

Resumo: Objective: To review the efficacy of anticancer peptide conjugation with cisplatin therapies in the treatment of oral cancer. Methods: The data search comprised the databases BVS, Scielo and PubMed, using the combination of the descriptors "anticancer peptides" AND "oral cancer" AND "cisplatin". Only 07 articles in English and Portuguese, published at last 10 years, were approved after eligibility analysis. Results: It was noted that there was more cytotoxicity and apoptosis, in addition to tumor regression, with the use of various peptides and binding proteins, associated with cisplatin in oral cancers. The peptide-drug conjugation may be established only after observing which oncogenes promote cell survival, proliferation and motility in tumorigenesis. Therefore, the oncogenes MiR-15b, ELF5A2, BCL-2, MDR1, were the ones that brought the highest results of protein inhibition and gene expression of multidrug resistance, without affecting the mesenchymal-epithelial transition of normal cells, and even a transient significant positive regulation, of systemic CD8 + T-cell antitumor. Conclusion: The tumor resistance to chemotherapeutic drugs, such as cisplatin, reduces treatment efficacy especially in advanced or recurrent cases. So, the association proposed above has potential synergistic therapeutic effect in oral cancer. However, further studies with a significant sample are needed.

Autor 1:  Marco TORIBIO

E-mail 1:  [email protected]

Autor 2:   Enzo Lustosa CAMPOS

E-mail 2:  [email protected]

Autor 3 :  Gabriela Jacób MONTEIRO

E-mail 3:  [email protected]

Autor 4:  João César Guimarães HENRIQUES

E-mail 4:  [email protected]

Autor 5:  Wigney Junior Carvalho GONZAGA

E-mail 5:  [email protected]

Autor 6:  Esteban Nicolas LORENZON

E-mail 6:  [email protected]

Autor 7:  Carla Silva Siqueira MIRANDA

E-mail 7:  [email protected]