NUMERO: #20230005

Título: QUANTIFICATION OF TORQUE TENO VIRUS (TTV) IN PLASMA AND SALIVA OF INDIVIDUALS WITH LIVER CIRRHOSIS

Nome do Apresentador: Gabriella Bueno MARINHO

Categoria do Trabalho: Painel de pesquisa científica (PPC)

Área Temática: Odontologia para pacientes especiais

Resumo: Cirrhosis-associated immune dysfunction is a complication of liver failure and torque teno virus (TTV) has been pointed as an endogenous marker of immune function. Objective: to investigate the TTV viral load in the plasma and saliva of cirrhotic individuals and correlate it with clinical characteristics. Study Design: clinical data, plasma and saliva were collected from 72 cirrhotic patients. Results: they were predominantly male (n=51; 70.8%), with median age of 57 years old and median value of MELD was 15. 59,7% of the patients presented decompensated cirrhosis and 47.2% had alterations in the white blood series. TTV was identified in 28 specimens of plasma (38.8%) and in 67 specimens of saliva (93.0%), with median values of TTV copies/mL of 90.6 in plasma and 245.14 in saliva. All the patients were positive for TTV in plasma and saliva, both fluids having a moderately positive correlation for the presence of TTV (Spearman's correlation coefficient = 0.576; P = 0.001). There was no correlation between TTV viral load, either in plasma or in saliva, and any of the variables studied (P > 0.05). Conclusion: There was no correlation between TTV viral load and clinical parameters.

Autor 1:  Gabriella Bueno MARINHO

E-mail 1:  [email protected]

Autor 2:   Ana Clara Falabello de LUCA

E-mail 2:  [email protected]

Autor 3 :  Juliana Bertoldi FRANCO

E-mail 3:  [email protected]

Autor 4:  Alexandre Mendes BATISTA

E-mail 4:  [email protected]

Autor 5:  Ana Carolina MAMANA

E-mail 5:  [email protected]

Autor 6:  Paulo Henrique BRAZ-Silva

E-mail 6:  [email protected]

Autor 7:  Karem Lopez ORTEGA

E-mail 7:  [email protected]