Título: Low-Grade Myofibroblastic Sarcoma of the oral cavity
Nome do Apresentador: Daniela Giraldo ROLDAN
Categoria do Trabalho: Trabalhos Aprovados para Disponibilização em Vídeo (ADV)
Área Temática: Patologia Oral
Resumo: Low-grade myofibroblastic sarcoma (LGMS) represents a distinct atypical myofibroblastic tumor of deep soft tissues, with a head and neck predilection. It has a variety of appearances, from fasciitis-like or fibromatosis-like to fibrosarcoma-like. Here, a series of four cases from two different institutions is shown, represented by 2 men and 2 women presenting a nodular lesion, with equal distribution in maxilla and mandibula. Microscopically, all cases showed a neoplasm formed by oval to spindle cells in a fibrous stroma with myxoid and dense areas, some atypical mitoses, and prominent nucleoli. These findings suggested a mesenchymal tumor. An immunohistochemical panel was performed, which showed positivity for smooth muscle actin (3 of 4 cases), HHF35 (2 of 4 cases), β-catenin (3 of 3 cases), calponin (2 of 4 cases) and Ki-67 (range 5-40%). H-Caldesmon was negative for all cases, demonstrating myofibroblastic and smooth muscle differentiation.The diagnosis of LGMS was confirmed in all cases.
Autor 1: Daniela Giraldo ROLDAN
E-mail 1: [email protected]
Autor 2: Brendo Vinícius Rodrigues LOUREDO
E-mail 2: [email protected]
Autor 3 : Ana Luiza Oliveira Corrêa ROZA
E-mail 3: [email protected]
Autor 4: Carla Isabelly Rodrigues-FERNANDES
E-mail 4: [email protected]
Autor 5: Alan Roger dos Santos-Silva
E-mail 5: [email protected]
Autor 6: Hélder Antônio Rebelo Pontes
E-mail 6: [email protected]
Autor 7: Pablo Agustin Vargas.
E-mail 7: [email protected]
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